浙江
來源：iNature
2026 年 7 月 20 日，鄒明輝團隊在 Diabetes 雜志上發表的 2 篇研究論文被撤回。
這兩篇論文分別發表于 2010 年 3 月 18 日（題為「Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo」）和 2009 年 10 月 26 日（題為「In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I」 ）。
此次撤稿由美國糖尿病協會（ADA）應俄克拉荷馬大學健康校區的要求執行，主要原因是糾正因數據不可靠而造成的研究記錄問題。
俄克拉荷馬大學健康校區對文章中數據真實性的調查得出結論：
圖 4C 是偽造的，其內容為重復使用并重新標注了來自先前已撤稿出版物中的免疫印跡（Diabetes 2008;57:3222–3230. DOI: Link to Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes10.2337/db08-0610），且未注明出處。
具體造假內容如下所述：
圖 4C 中 β-actin 印跡的第 1–3 條泳道經由 2008 年文章重新使用，其比例已調整，該文章中這些泳道在圖 5A 中被報告為 c-Jun 印跡+/-AICAR 處理的第 1–3 條泳道，在圖 6C 中則作為 C57BL6 樣本的 IP:PGIS/WB:PGIS 印跡的第 1–3 條泳道。
圖 4C 中 β-actin 印跡的第 4–6 條泳道在 2008 年文章中已重復使用，其比例已調整。該泳道在圖 5A 中作為 p-38 印跡+/-AICAR 處理的第 1–3 條泳道，在圖 6C 中作為 IP:PGIS/WB:PGIS 印跡的第 4–6 條泳道（AMPKα2 敲除樣本）使用。
已被撤回的 28 篇論文分別是：
1.Ablation of Adenosine Monophosphate-Activated Protein Kinase α1 in Vascular Smooth Muscle Cells Promotes Diet-Induced Atherosclerotic Calcification In Vivo,Circulation Research;
2.Adenosine monophosphate-activated protein kinase-α2 deficiency promotes vascular smooth muscle cell migration via S-phase kinase-associated protein 2 upregulation and E-cadherin downregulation,Arteriosclerosis, Thrombosis, and Vascular Biology;
3.Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite,Arteriosclerosis, Thrombosis, and Vascular Biology;
4.Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acid,American Journal of Physiology- Endocrinology and Metabolism;
5.AMPKα2 Deletion Exacerbates Neointima Formation by Upregulating Skp2 in Vascular Smooth Muscle Cells,Circulation Research;
6.Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner,Circulation;
7.Myeloperoxidase deletion prevents high-fat diet-induced obesity and insulin resistance，Diabetes；
8.Activation of AMP-activated protein kinase α1 alleviates endothelial cell apoptosis by increasing the expression of anti-apoptotic proteins Bcl-2 and Survivin，Journal of Biological Chemistry；
9.Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells: Role of peroxynitrite，Journal of Biological Chemistry；
10.Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo : Role of mitochondrial reactive nitrogen species，Journal of Biological Chemistry；
11.Activation of protein phosphatase 2A by palmitate inhibits AMP-activated protein kinase，Journal of Biological Chemistry；
12.Identification of nitric oxide as an endogenous activator of the AMP-activated protein kinase in vascular endothelial cells，Journal of Biological Chemistry；
13.Nicotine-induced activation of AMP-activated protein kinase inhibits fatty acid synthase in 3T3L1 adipocytes: A role for oxidant stress，Journal of Biological Chemistry；
14.Protein kinase Cζ-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells，Journal of Biological Chemistry；
15.Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo，Journal of Biological Chemistry；
16.Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling，Journal of Biological Chemistry；
17.Hypochlorous acid via peroxynitrite activates protein kinase Cθ and insulin resistance in adipocytes，Journal of Molecular Endocrinology；
18.Activation of the AMP-activated protein kinase (AMPK) by nitrated lipids in endothelial cells，PLOS ONE；
19.Peroxynitrite-Dependent Zinc Release and Inactivation of Guanosine 5'-Triphosphate Cyclohydrolase 1 Instigate Its Ubiquitination in Diabetes，Diabetes；
20.Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation，Diabetes；
21.Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes，Diabetes；
22.Regulation of the proteasome by AMPK in endothelial cells: the role of O-GlcNAc transferase (OGT)，PLOS ONE；
23.Tyrosine Nitration of PA700 Links Proteasome Activation to Endothelial Dysfunction in Mouse Models with Cardiovascular Risk Factors，PLOS ONE；
24.Transcription factor Krüppel-like factor 2 plays a vital role in endothelial colony forming cells differentiation，Cardiovascular Research；
25.Kynurenine promotes neonatal heart regeneration by stimulating cardiomyocyte proliferation and cardiac angiogenesis，Nature communications；
26.Proteasome-Dependent Degradation of Guanosine 5'-Triphosphate Cyclohydrolase I Causes Tetrahydrobiopterin Deficiency in Diabetes Mellitus，Circulation；
27.Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo，Diabetes；
28.In vivo activation of AMP-activated protein kinase attenuates diabetes-enhanced degradation of GTP cyclohydrolase I，Diabetes；
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